Dendritic Cell-Based Cancer Immunotherapy against Multiple Myeloma: From Bench to Clinic
Chonnam Medical Journal 2015³â 51±Ç 1È£ p.1 ~ p.7
(Hoang My-Dung) - Chonnam National University Hwasun Hospital Research Center for Cancer Immunotherapy
Á¤¼ºÈÆ(Jung Sung-Hoon) - Chonnam National University Hwasun Hospital Research Center for Cancer Immunotherapy
ÀÌÇöÁÖ(Lee Hyun-Ju) - Chonnam National University Hwasun Hospital Research Center for Cancer Immunotherapy
ÀÌÀ±°æ(Lee Youn-Kyung) - Vaxcell-Bio Therapeutics
(Thanh-Nhan Nguyen-Pham) - Chonnam National University Hwasun Hospital Research Center for Cancer Immunotherapy
(Choi Nu-Ri) - Chonnam National University Hwasun Hospital Research Center for Cancer Immunotherapy
(Manh-Cuong Vo) - Chonnam National University Hwasun Hospital Research Center for Cancer Immunotherapy
À̽½Å(Lee Seung-Shin) - Chonnam National University Hwasun Hospital Department of Hematology-Oncology
¾ÈÀç¼÷(Ahn Jae-Sook) - Chonnam National University Hwasun Hospital Department of Hematology-Oncology
¾ç´öȯ(Yang Deok-Hwan) - Chonnam National University Hwasun Hospital Department of Hematology-Oncology
±è¿©°æ(Kim Yeo-Kyeoung) - Chonnam National University Hwasun Hospital Department of Hematology-Oncology
±èÇüÁØ(Kim Hyeoung-Joon) - Chonnam National University Hwasun Hospital Department of Hematology-Oncology
ÀÌÁ¦Áß(Lee Je-Jung) - Chonnam National University Hwasun Hospital Research Center for Cancer Immunotherapy
Abstract
Although the introduction of stem cell transplantation and novel agents has improved survival, multiple myeloma (MM) is still difficult to cure. Alternative approaches are clearly needed to prolong the survival of patients with MM. Dendritic cell (DC) therapy is a very promising tool immunologically in MM. We developed a method to generate potent DCs with increased Th1 polarization and migration ability for inducing strong myeloma-specific cytotoxic T lymphocytes. In this review, we discuss how the efficacy of cancer immunotherapy using DCs can be improved in MM.
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Multiple myeloma, Dendritic cells, Immunotherapy
KMID :
0880520150510010001
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À¯È¿¼º°á°ú(Recomendation)
This review article discussed how the efficacy of cancer immunotherapy using DCs can be improved in MM.